Enantiomerenreine bicyclische pyrrolidin-derivate:
1991; Elsevier BV; Volume: 47; Issue: 7 Linguagem: Inglês
10.1016/s0040-4020(01)86377-8
ISSN1464-5416
AutoresJürgen Martens, Stefan Lübben,
Tópico(s)Asymmetric Synthesis and Catalysis
Resumo(1S, 5S)-2-Azabicyclo[3.3.0]octane (1S,5S)-2 was synthesized from (1S,3S,5S)-2-azabicyclo[3.3.0]octane-3-carboxylic acid (1S,3S,5S)-1 m 84% yield by decarboxyladon. The novel enantiomerically pure bicyclic pyrrolidine derivative (1S,5S)-2 was used as an efficient chiral auxiliary in Michael-type reactions via enamines.
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