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The search for nucleoside/nucleotide analog inhibitors of dengue virus

2015; Elsevier BV; Volume: 122; Linguagem: Inglês

10.1016/j.antiviral.2015.07.010

1872-9096

Yen‐Liang Chen, Fumiaki Yokokawa, Pei‐Yong Shi,

HIV/AIDS Research and Interventions

Nucleoside analogs represent the largest class of antiviral agents and have been actively pursued for potential therapy of dengue virus (DENV) infection. Early success in the treatment of human immunodeficiency virus (HIV) infection and the recent approval of sofosbuvir for chronic hepatitis C have provided proof of concept for this class of compounds in clinics. Here we review (i) nucleoside analogs with known anti-DENV activity; (ii) challenges of the nucleoside antiviral approach for dengue; and (iii) potential strategies to overcome these challenges. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.