Portal de Periódicos da CAPES

Mechanisms of Bone Lesions in Multiple Myeloma

1992; Elsevier BV; Volume: 6; Issue: 2 Linguagem: Inglês

10.1016/s0889-8588(18)30345-9

1558-1977

Régis Bataille, Daniel Chappard, Bernard Klein,

Myeloproliferative Neoplasms: Diagnosis and Treatment

Lytic bone lesions and hypercalcemia are common features of multiple myeloma; however, they are exceptional in other B-cell malignancies. Myeloma bone involvement is related to an uncoupling process associating an increased osteoclastic resorption with decreased bone formation. Several osteoclast-activating factors such as interleukin-1 (IL-1), tumor necrosis factor, and interleukin-6 (IL-6) are involved in this process. IL-6, the major myeloma cell growth factor, could play a critical role in myeloma-induced bone resorption in association with other known or unknown hematopoietic growth factors, however.