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Historical Introduction to the “Free Radical Theory” of Oxygen Toxicity

1981; Springer Nature; Linguagem: Inglês

10.1007/978-1-4612-5890-2_2

0172-6048

R. Gerschman,

Spaceflight effects on biology

It all started in 1952 while I was a Research Associate in the Physiology Department of the School of Medicine at the University of Rochester. At that time, the adrenal cortex was known to be stimulated by many stress-producing conditions. Furthermore, the release of the adrenal cortical hormones was shown in stress situations, such as hypoxia, to aid the organism to resist the adverse effects of the stress. Previously, with Dr. Bernardo Houssay here in Buenos Aires, I had performed experiments with the adrenal gland and the hormones in the medulla, studying its effects on the plasma potassium concentration.