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Quantifying carrier-mediated transport of peptides from the brain to the blood

1989; Academic Press; Linguagem: Inglês

10.1016/0076-6879(89)68047-0

1557-7988

William A. Banks, Abba J. Kastin,

Electrolyte and hormonal disorders

This chapter describes a method that allows the quantitative measurement of the rate of transport of peptides from the brain to the blood. It uses this method to study thyroid hormones, Tyr-MIF-1, methionine (Met)-enkephalin, arginine (Arg)-vasopressin (AVP), iodide, technetium pertechnetate, albumin, and peptide T. Some classes of peptides depart from the general principle and so suggest the existence of saturable transport systems. The best studied of these is the system that has been shown to transport Tyr-MIF-1 (Tyr-Pro-Leu-Gly-amide) and the enkephalins from the brain to the blood. Different methodologies have lent support to the idea that members of this group of peptides may cross the blood brain barrier (BBB), including the demonstration of saturable binding to the choroid plexus and to capillaries of the brain.