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Activation of Rabbit Skeletal Muscle Myosin Light Chain Kinase by Calmodulin- A Mechanistic Overview

1989; Springer Nature; Linguagem: Inglês

10.1007/978-1-4684-5679-0_17

2214-8019

Peter J. Kennelly, Melissa A. Starovasnik, Edwin G. Krebs,

Muscle Physiology and Disorders

The myosin light chain kinases [MLCK, E.C. 2.7.1.37] are a family of tissue-specific isozymes which share as their substrate the phosphoryl- or P-light chain.component of myosin. Distinct forms of MLCK have been isolated from smooth, skeletal, and cardiac muscle. The enzyme appears to be ubiquitous, with non-muscle MLCK envisaged as being very similar, if not identical, to the smooth muscle isozyme (For a review see (43)).