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Cytogenetics of soft tissue tumors

1997; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-1-4615-6121-7_2

2509-8497

Jonathan A. Fletcher,

Soft tissue tumors and treatment

The past decade has witnessed tremendous advances in our understanding of the chromosomal and DNA mutations responsible for soft tissue sarcomas. Many research groups have characterized cytogenetic and molecular genetic mutations in soft tissue sarcomas, and a surprising number of sarcoma mutations have proved to be specific for particular histologies (Tables 1 and 2). Virtually all malignant soft tissue tumors contain clonal cytogenetic aberrations [1–4], and clonal cytogenetic aberrations are also found in many benign soft tissue tumors [2–4]. Sarcoma cytogenetic aberrations arise by diverse physical mechanisms. Common mechanisms include deletions, amplifications, and rearrangements of various chromosomal regions.