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Transmembrane Signals and Intracellular Messengers Mediating LHRH and LH Secretion

1987; Springer Nature; Linguagem: Inglês

10.1007/978-1-4684-5395-9_5

2214-8019

A. Negro‐Vilar, Marcelo Moraes Valênça, Michael D. Culler,

Sperm and Testicular Function

The gametogenic and endocrine functions of the gonads are both under the integrative control of the central nervous system. The primary regulatory component in this system is the hypothalamic peptide luteinizing hormone-releasing hormone (LHRH), a decapeptide produced by neurons located in the hypothalamic-preoptic region. After synthesis, LHRH is transported to nerve terminals located in the median eminence, where it is released in close proximity to portal capillaries. The decapeptide is then transported to the anterior pituitary gland through the hypophyseal portal circulation, where, acting on specific membrane receptors, it stimulates LH and FSH secretion. These gonadotropins, in turn, profoundly affect gonadal function.