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PRINCIPLES OF CONCOMITANT ANTIBIOTIC THERAPY

1977; Wiley; Volume: 2; Issue: SP3_Part2 Linguagem: Inglês

10.5694/j.1326-5377.1977.tb113912.x

1326-5377

Allan J. Weinstein,

Antibiotic Use and Resistance

There are five major disadvantages of the combined use of antibiotics: (i) antibiotic antagonism:; (ii) a “false sense of security”; (iii) increased toxicity; (iv) suprainfection; and (v) increased cost. Four situations clearly require the use of antibiotic combinations: (i) to produce antibiotic synergism; (ii) to prevent the emergence of resistant organisms; (iii) to treat mixed infections, such as brain abscess, peritonitis, and pelvic infections; and (iv) to institute therapy for severe infections.