Dietary Casein Levels and Aflatoxin B 1 Metabolism in Rainbow Trout (Salmo gairdneri)
1979; American Chemical Society; Linguagem: Inglês
10.1021/bk-1979-0099.ch023
ISSN1947-5918
AutoresWilliam T. Stott, R. O. Sinnhuber,
Tópico(s)Environmental Toxicology and Ecotoxicology
ResumoThe effect of dietary protein (casein) levels (32%, 42%, 52%, 62%) upon the activities of several hepatic activating and detoxifying enzyme systems of aflatoxin B1 (AFB) in rainbow trout (Salmo gairdneri) was investigated. It was observed that in fish fed increased casein, cytochrome P-450 content, in vitro epoxidase and glutathione epoxide transferase activity dropped, up to 21%, 32% and 25% respectively. Fish fed the higher levels of protein converted a greater amount of AFB to aflatoxicol and showed a 62% increase in AFB mutagen assay responses. In vitro cytochrome c reductase and epoxide hydrase activities were not observed to be affected by the diets. The enzyme data provided a possible explanation for the mutagen assay results.
Referência(s)