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Involvement of Tissue Inhibitors of Metalloproteinases (TIMPS) During Matrix Metalloproteinase Activation

1996; Springer Nature; Linguagem: Inglês

10.1007/978-1-4613-0335-0_3

2214-8019

Hideaki Nagase, Ko Suzuki, Yoshifumi Itoh, C. Kan, Chris Gehring, Wen Huang, Keith Brew,

Blood Coagulation and Thrombosis Mechanisms

Matrix metalloproteinases (MMPs), also termed "matrixins", constitute a family of zinc metalloendopeptidases that participate in breakdown of extracellular matrix macromolecules (Woessner, 1991). These enzymes are considered to play an important role in many biological processes such as in reproduction, embryogenesis, tissue resorption, and in the control of cell behavior. Overproduction of matrixins is associated with various connective tissue diseases such as arthritis, periodontitis, glomerulonephritis, tissue ulceration as well as being connected with tumor cell invasion and metastasis (Woessner, 1991; Birkedal-Hansen et al., 1993).