Histamine Releasing Factors and Cytokine-Dependent Activation of Basophils and Mast Cells
1991; Elsevier BV; Linguagem: Inglês
10.1016/s0065-2776(08)60826-3
ISSN1557-8445
AutoresAllen P. Kaplan, Sesha Reddigari, María Baeza, Piotr Kuna,
Tópico(s)Coagulation, Bradykinin, Polyphosphates, and Angioedema
ResumoThis chapter describes the various types of histamine releasing factors (HRFs), discusses their interaction with basophils or mast cells, and speculates regarding their role in inflammation in general, and in allergic diseases in particular. The release of histamine from human basophils or mast cells is typically initiated by the interaction of antigen with surface-bound immunoglobulin (IgE) antibody. Histamine releasing factors are defined as products of activated cells that interact with basophils and mast cells to cause the release of histamine. Two general types of HRFs is described, one whose function appears to be dependent upon cell surface IgE and others that are IgE independent. A variety of reports confirmed that lymphoid cells produce such a factor, and HRF-like activities are described as products of T lymphocytes, mixed mononuclear cells, alveolar macrophages, platelets, B lymphocytes, and neutrophils. Such activity also appeared to be present in nasal washings of allergic subjects and in antigen-challenged cutaneous late-phase reactions. Histamine releasing factors cause a noncytotoxic granule exocytosis from basophils when assessed by electron microscopy and cause histamine release as well as release of lipid mediators such as leukotriene C4.
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