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Correlation of Altered Penile Ultrastructure with Clinical Arterial Evaluation

1989; Lippincott Williams & Wilkins; Volume: 142; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)39127-9

1527-3792

Charlotta Persson, W. Diederichs, Tom F. Lue, T. S. Benedict Yen, Irving J. Fishman, Patrick H. McLin, Emil A. Tanagho,

Prostate Cancer Diagnosis and Treatment

No AccessJournal of Urology1 Dec 1989Correlation of Altered Penile Ultrastructure with Clinical Arterial Evaluation Charlotta Persson, Wolfgang Diederichs, Tom F. Lue, T.S. Benedict Yen, Irving J. Fishman, Patrick H. Mclin, and Emil A. Tanagho Charlotta PerssonCharlotta Persson , Wolfgang DiederichsWolfgang Diederichs , Tom F. LueTom F. Lue , T.S. Benedict YenT.S. Benedict Yen , Irving J. FishmanIrving J. Fishman , Patrick H. MclinPatrick H. Mclin , and Emil A. TanaghoEmil A. Tanagho View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39127-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We investigated the ultrastructural changes in the penile erectile tissue from 32 consecutive patients who underwent penile prosthesis implantation. Because most of the patients had undergone papaverine injection with or without duplex ultrasonography, we compared these results with the electron microscopic findings. In patients with a good arterial response and full erection after papaverine injection the ultrastructural findings were similar to those reported in normal men. In patients with moderate arterial disease a distinct increase in mitochondria with aggregation and cytoplasmic vacuolization in smooth muscle cells was noted. These findings could be interpreted as an active cellular attempt to respond to the altered environmental and nutritive situation. In patients with severe arterial insufficiency the cellular structure was markedly altered, the number of intracavernous smooth muscle cells was reduced and the density of the connective tissue separating individual cells was increased. These changes in the smooth muscle cells consisted of contour irregularity with fragmentation and loss of the basal lamina. The cytoplasm was largely devoid of contractile elements. The nuclei tended to be pleomorphic with unevenly distributed chromatin. The endothelium was also altered significantly in this group. A careful clinical evaluation of penile arterial function should be performed in all patients undergoing penile arterial or venous corrective surgery. If doubt remains, a penile biopsy may be indicated. © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byIACONO F, GIANNELLA R, SOMMA P, MANNO G, FUSCO F and MIRONE V (2018) HISTOLOGICAL ALTERATIONS IN CAVERNOUS TISSUE AFTER RADICAL PROSTATECTOMYJournal of Urology, VOL. 173, NO. 5, (1673-1676), Online publication date: 1-May-2005.ELHANBLY S, SCHOOR R, ELMOGY M, ROSS L, HEGAZY A and NIEDERBERGER C (2018) WHAT NONRESPONSE TO INTRACAVERNOUS INJECTION REALLY INDICATES: A DETERMINATION BY QUANTITATIVE ANALYSISJournal of Urology, VOL. 167, NO. 1, (192-196), Online publication date: 1-Jan-2002.NEHRA A, GETTMAN M, NUGENT M, BOSTWICK D, BARRETT D, GOLDSTEIN I, KRANE R and MORELAND R (2018) TRANSFORMING GROWTH FACTOR-beta1 (TGF-beta1) IS SUFFICIENT TO INDUCE FIBROSIS OF RABBIT CORPUS CAVERNOSUM IN VIVOJournal of Urology, VOL. 162, NO. 3 Part 1, (910-915), Online publication date: 1-Sep-1999.WESPES E, RAVIV G, VANEGAS J, DECAESTECKER C, 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(2018) Reply by AuthorsJournal of Urology, VOL. 146, NO. 5, (1379-1380), Online publication date: 1-Nov-1991.Mersdorf A, Goldsmith P, Diederichs W, Padula C, Lue T, Fishman I and Tanagho E (2018) Ultrastructural Changes in Impotent Penile Tissue: A Comparison of 65 PatientsJournal of Urology, VOL. 145, NO. 4, (749-758), Online publication date: 1-Apr-1991.Vickers M, Seiler M and Weidner N (2018) Corpora Cavernosa Ultrastructure in Vascular Erectile DysfunctionJournal of Urology, VOL. 143, NO. 6, (1131-1134), Online publication date: 1-Jun-1990. Volume 142Issue 6December 1989Page: 1462-1468 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Charlotta Persson More articles by this author Wolfgang Diederichs More articles by this author Tom F. Lue More articles by this author T.S. Benedict Yen More articles by this author Irving J. Fishman More articles by this author Patrick H. Mclin Deceased. 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