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A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

2015; Nature Portfolio; Volume: 5; Issue: 1 Linguagem: Inglês

10.1038/srep13543

2045-2322

Huan He, Dongwei Li, Liyun Yang, Li Fu, Xunjin Zhu, Wai‐Kwok Wong, Feng‐Lei Jiang, Yi Liu,

Mitochondrial Function and Pathology

Abstract Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.