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Chapter 32 A phenotypic analysis of T lymphocytes isolated from the brains of mice with allogeneic neural transplants

1988; Elsevier BV; Linguagem: Inglês

10.1016/s0079-6123(08)60291-5

1875-7855

M. Kelly Nicholas, Oren Sagher, J. P. Hartley, Kāri Stefánsson, Barry G.W. Arnason,

Nerve injury and regeneration

This chapter describes the phenotypic analysis of T cells isolated from the brains of mice with iso- and allogeneic intraventricular neural transplants. The chapter indicates the preponderance of MHC class II restricted T lymphocytes in most neural allografts when mice differ completely at the MHC and at mH loci. Depletion of class II-restricted T cells in host mice permits the survival of fully histoincompatible orthotopic skin grafts, while depletion of class I-restricted cells does not. Although, class II-restricted cells are often functionally defined as helper cells, they can clearly effect cytotoxic functions as well, an activity, which predominates in the class I-restricted subset. The target(s) of the immune response observed in intraventricular allografts is unknown. While class I antigen expression on neurons can be induced in vitro with interferons, class II antigen expression has not been convincingly demonstrated. This relative resistance to inducible MHC antigen expression may confer selective privilege to neurons, especially if class II MHC restriction proves to play a pivitol role in the rejection process.