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Crosstalk Between the SUMO and Ubiquitin Pathways

2008; Springer Science+Business Media; Linguagem: Inglês

10.1007/2789_2008_098

1866-9425

Tony Hunter, Huaiyu Sun,

Cancer-related Molecular Pathways

Several ways in which the SUMO and ubiquitin pathways can intersect and communicate have recently been discovered. This review discusses the principles of crosstalk between SUMOylation and ubiquitination, focusing on the RNF4 family of RING finger E3 ubiquitin ligases, which specifically recognize SUMOylated proteins via their SUMO moiety for ubiquitination.