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Telomerase inhibitors in cancer therapy: current status and future directions.

2003; National Institutes of Health; Volume: 4; Issue: 6 Linguagem: Inglês

Christopher M. Incles, Christoph Schultes, Stephen Neidle,

DNA and Nucleic Acid Chemistry

The ends of chromosomes (telomeres) are subject to progressive shortening in normal somatic cells, leading ultimately to irreversible growth arrest. In contrast, telomeres in all cancer cells are stabilized in length and effectively immortalized by the enzyme telomerase, which catalyzes the synthesis of telomeric DNA repeats. Several strategies have been devised for the inhibition of telomerase in the hope that this will result in anticancer effects. The principal approaches of catalytic inhibitors, antisense to the template, and folding of the DNA substrate, are reviewed and critically evaluated for their potential in anticancer therapy.