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High fat diet alters hormone profiles and reproductive organs mass

2015; Wiley; Volume: 29; Issue: S1 Linguagem: Inglês

10.1096/fasebj.29.1_supplement.685.10

1530-6860

Cynthia Soares da Silva, Aline dos Santos, Rejane Gaspar Reis, Celly Cristina Alves do Nascimento‐Saba,

Sperm and Testicular Function

Amount of body fat stored is known to influence fertility, but the exact mechanism connecting these processes is still not fully known. The aim of the study was to evaluate the effect of high fat diet, containing soybean oil, on organs mass and body composition of male reproductive system of young rats. Male Wistar rats were fed with control (C) or high fat (HF) diet (7% and 19% of soybean oil, respectively) from weaning until 30 or 60 days of age. Food intake and body mass were monitored weekly. Body composition was evaluated by DEXA on the eve of euthanasia. Blood, liver, adipose tissue, testis and epidydimis were collected. Triglycerides, cholesterol, HDL, VLDL, insulin, leptin and testosterone were assessed. Qualitative characteristics of testis were evaluated by morphometry. Food intake, body mass gain and total fat mass did not differ between the groups at 30 and 60 days. At 30 days, testosterone increased in rats fed with HF (1.35±1.09 vs 10.89± 1.12). At 60 days, epididymal adipose tissue mass (2.90±0.07 vs 3.14±0.10), liver (8.40±0.14 vs 10.45±0.55) and epididymis (0.30±0.18 vs 0.41±0.02) were higher after HF ingestion. Leptin and testis mass were higher in HF group at 30 days (0.85±0.13 vs 1.45±0.16; 1.57±0.06 vs 2.53±0.18) and 60 days of age (0.37±0.03 vs 0.46±0.04; 1.55±0.03 vs 1.66±0.05), respectively. In regard to morphological analyses, at 60 days, testis area was increased (31.87±0.98 vs 37.17±1.97), while seminiferous tubules was decreased (102.7±5.29 vs 79.75±4.21) in Hf groups. In conclusion, some results suggest that HF diet promotes increase in epidydimis and testis, as well as, the results of testis morphometry in these young animals.