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Towards a Vaccine Against AIDS: Lessons from Simian Immunodeficiency Virus Vaccines

1994; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-78536-8_12

2196-9965

E. J. Stott,

Virology and Viral Diseases

The discovery in 1983 that HIV-1 is the causative agent of AIDS stimulated a widespread search for an animal model in which prophylactic vaccines and therapeutic approaches could be assessed. A wide range of mammals, including several species of non-human primates, were inoculated with strains of HIV-1 (Gibbs et al. 1986). It soon appeared that only chimpanzees and gibbon apes were susceptible to infection by HIV-1. However, their use in AIDS research was severely limited because these animals are rare and protected species. Furthermore, persistently infected chimpanzees did not appear to develop the characteristic clinical signs of AIDS. Alternative animal models for AIDS and HIV infection in man were sought.