The UCLA-University of Utah epidemiologic survey of autism: recurrence risk estimates and genetic counseling
1989; American Psychiatric Association; Volume: 146; Issue: 8 Linguagem: Inglês
10.1176/ajp.146.8.1032
ISSN1535-7228
AutoresEdward Ritvo, Lynn B. Jorde, A Mason-Brothers, B. J. Freeman, Carmen Pingree, Malia Jones, William M. McMahon, P. Brent Petersen, William R. Jenson, A Mo,
Tópico(s)Autism Spectrum Disorder Research
ResumoBack to table of contents Previous article Next article No AccessThe UCLA-University of Utah epidemiologic survey of autism: recurrence risk estimates and genetic counselingPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.146.8.1032AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractThe authors recently reported, in this journal, an epidemiologic survey of autism in Utah. Twenty (9.7%) of the 207 families ascertained had more than one autistic child. Analyses of these data revealed that autism is 215 times more frequent among the siblings of autistic patients than in the general population. The overall recurrence risk estimate (the chance that each sibling born after an autistic child will develop autism) is 8.6%. If the first autistic child is a male the recurrence risk estimate is 7%, and if a female 14.5%. These new recurrence risk estimates should be made available to all individuals who have autistic children and are interested in family planning. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byCan the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder?Neuron, Vol. 110, No. 20Advancing research on early autism through an integrated risk and resilience perspective5 April 2022 | Development and Psychopathology, Vol. 1Awareness and perception of medical genetic services among Malaysian parents of autism spectrum disorders children: the lessons to be learned21 June 2021 | Advances in Autism, Vol. 8, No. 1Predicting the Risk Genes of Autism Spectrum Disorders14 June 2021 | Frontiers in Genetics, Vol. 12Using the tools of genetic epidemiology to understand sex differences in neuropsychiatric disorders22 June 2020 | Genes, Brain and Behavior, Vol. 19, No. 6Consanguinity and Autism13 January 2020 | Current Psychiatry Reports, Vol. 22, No. 1Understanding environmental contributions to autism: Causal concepts and the state of science23 March 2018 | Autism Research, Vol. 11, No. 4Autism Spectrum DisorderEnvironmental Health Perspectives, Vol. 125, No. 1Eye-Tracking TechnologyIs the Risk of Autism in Younger Siblings of Affected Children Moderated by Sex, Race/Ethnicity, or Gestational Age?Journal of Developmental & Behavioral Pediatrics, Vol. 37, No. 8Prevalence of Autism Spectrum Disorders in Siblings of Indian Children With Autism Spectrum Disorders5 January 2016 | Journal of Child Neurology, Vol. 31, No. 7Epilepsia, Vol. 57, No. 12Frontiers in Genetics, Vol. 7International Journal of Molecular Sciences, Vol. 17, No. 2Identification of infants at high‐risk for autism spectrum disorder using multiparameter multiscale white matter connectivity networks14 September 2015 | Human Brain Mapping, Vol. 36, No. 12Early Infant Development and Intervention for Autism Spectrum Disorder31 August 2015 | Journal of Child Neurology, Vol. 30, No. 14Early Screening of Autism Spectrum Disorder: Recommendations for Practice and Research1 October 2015 | Pediatrics, Vol. 136, No. Supplement_1Autism Research, Vol. 8, No. 1Science China Life Sciences, Vol. 58, No. 10Journal of Molecular Neuroscience, Vol. 57, No. 4Research in Autism Spectrum Disorders, Vol. 17Clinical Genetics, Vol. 88, No. 2Clinical Genetics, Vol. 88, No. 2International Journal of Molecular Sciences, Vol. 16, No. 12Familial Recurrence of Autism Spectrum Disorder: Evaluating Genetic and Environmental ContributionsNeil Risch, Ph.D. Thomas J. Hoffmann, Ph.D. Meredith Anderson, M.S. Lisa A. Croen, Ph.D. Judith K. Grether, Ph.D. Gayle C. Windham, Ph.D.1 November 2014 | American Journal of Psychiatry, Vol. 171, No. 11Journal of Autism and Developmental Disorders, Vol. 44, No. 2The neurobiology of autism spectrum disorders15 April 2020 | European Psychiatry, Vol. 29, No. 1A Trend Analysis of Participant and Setting Characteristics in Autism Intervention Research5 December 2012 | Focus on Autism and Other Developmental Disabilities, Vol. 28, No. 3Linking Infant-Directed Speech and Face Preferences to Language Outcomes in Infants at Risk for Autism Spectrum DisorderJournal of Speech, Language, and Hearing Research, Vol. 56, No. 2neurogenetics, Vol. 14, No. 2Journal of Autism and Developmental Disorders, Vol. 43, No. 3Journal of Autism and Developmental Disorders, Vol. 43, No. 9Journal of Autism and Developmental Disorders, Vol. 43, No. 11Current Problems in Pediatric and Adolescent Health Care, Vol. 43, No. 1Medical Hypotheses, Vol. 81, No. 3Clinical Genetics, Vol. 83, No. 5Infancy, Vol. 18, No. 5Journal of Neurodevelopmental Disorders, Vol. 5, No. 1Role of NAD + , Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders21 July 2013 | International Journal of Tryptophan Research, Vol. 6s1Infant siblings and the investigation of autism risk factors18 April 2012 | Journal of Neurodevelopmental Disorders, Vol. 4, No. 1Effective Strategies for the Inclusion of Children With Autism in General Education Classrooms3 May 2012 | Behavior Modification, Vol. 36, No. 3The Autistic Spectrum Disorders30 March 2012Pragmatic Language in Autism and Fragile X Syndrome: Genetic and Clinical ApplicationsPerspectives on Language Learning and Education, Vol. 19, No. 2American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 159B, No. 1Journal of Autism and Developmental Disorders, Vol. 42, No. 4Journal of Autism and Developmental Disorders, Vol. 42, No. 12, Vol. 106Journal of Reproductive Immunology, Vol. 93, No. 1Pediatric Clinics of North America, Vol. 59, No. 1Neuropsychopharmacology, Vol. 37, No. 1Brain, Vol. 135, No. 11Autism Research and Treatment, Vol. 2012Autism Research and Treatment, Vol. 2012Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study1 September 2011 | Pediatrics, Vol. 128, No. 3Unravelling the genetics of autism spectrum disordersJournal of Autism and Developmental Disorders, Vol. 41, No. 3Journal of Autism and Developmental Disorders, Vol. 41, No. 7Genetics and Vascular Biology of Brain Vascular MalformationsMedical Hypotheses, Vol. 77, No. 6Seminars in Pediatric Neurology, Vol. 18, No. 1Translational Psychiatry, Vol. 1, No. 7Genetics in Medicine, Vol. 13, No. 4Cytogenetic and Genome Research, Vol. 135, No. 3-4BMC Medicine, Vol. 9, No. 1PLoS ONE, Vol. 6, No. 9Social demographic change and autismDemography, Vol. 47, No. 2Advances in the early detection of autismCurrent Opinion in Neurology, Vol. 23, No. 2Infants and Toddlers With Autism Spectrum Disorder: Early Identification and Early Intervention7 April 2010 | Journal of Early Intervention, Vol. 32, No. 2Der Nervenarzt, Vol. 81, No. 11Brain and Development, Vol. 32, No. 2Journal of Child Psychology and Psychiatry, Vol. 51, No. 9PLoS ONE, Vol. 5, No. 9Enfance, Vol. 2010, No. 03Novel copy number variants in children with autism and additional developmental anomalies27 May 2009 | Journal of Neurodevelopmental Disorders, Vol. 1, No. 4Journal of Autism and Developmental Disorders, Vol. 39, No. 1Biological Psychiatry, Vol. 66, No. 10Child and Adolescent Psychiatric Clinics of North America, Vol. 18, No. 3Human Immunology, Vol. 70, No. 3Neuroscience, Vol. 163, No. 4Psychiatric Disorders in Clinical Genetics II: Individualizing Recurrence Risks11 December 2007 | Journal of Genetic Counseling, Vol. 17, No. 1, Vol. 105Development and Psychopathology, Vol. 20, No. 3Human Molecular Genetics, Vol. 17, No. 24Developmental Medicine & Child Neurology, Vol. 35, No. 9Developmental Medicine & Child Neurology, Vol. 36, No. 8Developmental Medicine & Child Neurology, Vol. 50, No. 1The Epidemiology of Autism Spectrum DisordersAnnual Review of Public Health, Vol. 28, No. 1Journal of Autism and Developmental Disorders, Vol. 37, No. 3Journal of Autism and Developmental Disorders, Vol. 37, No. 3Journal of Autism and Developmental Disorders, Vol. 37, No. 1Biological Psychiatry, Vol. 62, No. 9Research in Developmental Disabilities, Vol. 28, No. 4Health & Social Care in the Community, Vol. 1, No. 4Developmental Medicine & Child Neurology, Vol. 47, No. 8Journal of Human Genetics, Vol. 51, No. 6Journal of Developmental and Physical Disabilities, Vol. 18, No. 4Human Immunology, Vol. 67, No. 1-2Journal of Developmental & Behavioral Pediatrics, Vol. 27, No. Supplement 2Journal of Child Psychology and Psychiatry, Vol. 47, No. 6Environmental Health Perspectives, Vol. 114, No. 7Medical Aspects of Autism30 September 2013American Journal of Medical Genetics Part A, Vol. 132A, No. 4Journal of Autism and Developmental Disorders, Vol. 35, No. 5, Vol. 30BMC Medical Genetics, Vol. 6, No. 1American Journal of PharmacoGenomics, Vol. 5, No. 2The Genetics of Autism1 May 2004 | Pediatrics, Vol. 113, No. 5Clinical Genetics, Vol. 65, No. 5Genetic and Neurodevelopmental Influences in Autistic Disorder1 October 2003 | The Canadian Journal of Psychiatry, Vol. 48, No. 8Neurologic Clinics, Vol. 21, No. 4Practical Neurology, Vol. 3, No. 3Annals of Medicine, Vol. 35, No. 4Absence of association between a polymorphic GGC repeat in the 5′ untranslated region of the reelin gene and autism23 August 2002 | Molecular Psychiatry, Vol. 7, No. 7Linkage and association of the glutamate receptor 6 gene with autism22 March 2002 | Molecular Psychiatry, Vol. 7, No. 3American Journal of Medical Genetics, Vol. 114, No. 1The American Journal of Human Genetics, Vol. 71, No. 4The American Journal of Human Genetics, Vol. 71, No. 4Mental Retardation and Developmental Disabilities Research Reviews, Vol. 7, No. 1The American Journal of Human Genetics, Vol. 69, No. 2American Journal of Medical Genetics, Vol. 91, No. 4Familial Clustering of Autoimmune Disorders and Evaluation of Medical Risk Factors in Autism2 July 2016 | Journal of Child Neurology, Vol. 14, No. 6American Journal of Medical Genetics, Vol. 88, No. 6Biological Psychiatry, Vol. 45, No. 5Psychiatric Clinics of North America, Vol. 21, No. 4Broader autism phenotype: evidence from a family history study of multiple-incidence autism families1 April 2006 | American Journal of Psychiatry, Vol. 154, No. 2New England Journal of Medicine, Vol. 337, No. 2Journal of Child Psychology and Psychiatry, Vol. 38, No. 8Head Circumference Measurements in Children With Autism2 July 2016 | Journal of Child Neurology, Vol. 11, No. 5American Journal of Medical Genetics, Vol. 67, No. 1American Journal of Medical Genetics, Vol. 67, No. 4Journal of Autism and Developmental Disorders, Vol. 26, No. 4Biological Psychiatry, Vol. 40, No. 6Psychiatry Research, Vol. 65, No. 1The Journal of Psychology, Vol. 130, No. 2Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 35, No. 4American Journal of Medical Genetics, Vol. 60, No. 4Developmental Neuropsychology, Vol. 11, No. 1American Journal of Medical Genetics, Vol. 54, No. 1Biological Psychiatry, Vol. 35, No. 4Comprehensive Psychiatry, Vol. 35, No. 2International Journal of Pediatric Otorhinolaryngology, Vol. 30, No. 2Child and Adolescent Psychiatric Clinics of North America, Vol. 3, No. 1Psychological Medicine, Vol. 24, No. 3Journal of Child Psychology and Psychiatry, Vol. 35, No. 5European Child & Adolescent Psychiatry, Vol. 2, No. 2Personality and Individual Differences, Vol. 14, No. 3, Vol. 35Psychoanalytic Inquiry, Vol. 13, No. 1Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 32, No. 6Magnetic resonance imaging of the posterior fossa in autistic adults1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 2Journal of Clinical Child Psychology, Vol. 21, No. 4Autism29 June 2016 | School Psychology International, Vol. 12, No. 4Journal of Psychopathology and Behavioral Assessment, Vol. 13, No. 2Psychiatric Clinics of North America, Vol. 14, No. 1Journal of Child Psychology and Psychiatry, Vol. 32, No. 6Archives of Disease in Childhood, Vol. 66, No. 5The UCLA-University of Utah epidemiologic survey of autism: the etiologic role of rare diseases1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 12Relationships of whole blood serotonin and plasma norepinephrine within familiesJournal of Autism and Developmental Disorders, Vol. 20, No. 4American Journal of Medical Genetics, Vol. 36, No. 1Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 29, No. 6 Volume 146Issue 8 August 1989Pages 1032-1036 Metrics PDF download History Published online 1 April 2006 Published in print 1 August 1989
Referência(s)