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Clinical and Therapeutic Aspects of Childhood Narcolepsy-Cataplexy: A Retrospective Study of 51 Children

2010; Oxford University Press; Volume: 33; Issue: 11 Linguagem: Inglês

10.1093/sleep/33.11.1457

1550-9109

Adi Aran, Mali Einen, Ling Lin, Giuseppe Plazzi, Seiji Nishino, Emmanuel Mignot,

Circadian rhythm and melatonin

Design, Patients, and Setting:Retrospective series of 51 children who completed the Stanford Sleep Inventory. HLA-DQB1*0602 typing (all tested, and 100% positive), polysomnography or Multiple Sleep Latency Test (76%), and cerebrospinal fluid hypocretin-1 measurements (26%, all with low levels) were also conducted. Prospective data on medication response was collected in 78% using a specially designed questionnaire.