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Review: IRF-1 as a Negative Regulator of Cell Proliferation

2002; Mary Ann Liebert, Inc.; Volume: 22; Issue: 1 Linguagem: Inglês

10.1089/107999002753452647

1557-7465

G. Romeo, Gianna Fiorucci, Maria Vincenza Chiantore, Zulema Percario, Serena Vannucchi, Elisabetta Affabris,

Retinoids in leukemia and cellular processes

Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers.