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Small Cell Carcinoma of the Genitourinary Tract: An Immunohistochemical, Electron Microscopic and Clinicopathological Study

1991; Lippincott Williams & Wilkins; Volume: 146; Issue: 2 Part 1 Linguagem: Inglês

10.1016/s0022-5347(17)37800-x

1527-3792

Mark E. Christopher, Allen D. Seftel, Kelly Sorenson, Martin I. Resnick,

Prostate Cancer Treatment and Research

No AccessJournal of Urology1 Aug 1991Small Cell Carcinoma of the Genitourinary Tract: An Immunohistochemical, Electron Microscopic and Clinicopathological Study Mark E. Christopher, Allen D. Seftel, Kelly Sorenson, and Martin I. Resnick Mark E. ChristopherMark E. Christopher , Allen D. SeftelAllen D. Seftel , Kelly SorensonKelly Sorenson , and Martin I. ResnickMartin I. Resnick View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37800-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We examined 13 cases of small cell carcinoma of the genitourinary tract to evaluate and compare the immunocytochemical and ultrastructural features as well as the clinicopathological behavior. Immunohistochemical stains revealed that neuron specific enolase and chromogranin showed differences in staining between the bladder and prostate, as well as between the small cell and adenocarcinomatous components of the prostate. Also, synaptophysin was negative over-all in 12 of 13 cases. Epithelial membrane antigen, carcinoembryonic antigen and keratin showed strong focal positivity within the small cell component. Electron microscopy was performed in 4 cases, with 3 demonstrating neurosecretory granules. Clinically, 6 of the 7 patients with adenocarcinoma/small cell carcinoma of the prostate did poorly, all with a survival of 15 months or less. Of 5 patients with transitional cell/small cell carcinoma of the bladder 2 fared better (both had no evidence of disease at 12 months and 11 years, respectively). Based upon the immunostaining and electron microscopic findings, small cell carcinoma of the genitourinary tract is heterogeneous in appearance and, therefore, may arise from a multipotential cell of origin. This cell of origin may be organ-specific, as demonstrated by the variability in staining characteristics among the prostate, bladder and kidney, as well as by the differences in the clinical behavior of these malignancies. Small cell carcinoma of the prostate has a poor prognosis, while small cell carcinoma of the bladder may portend a better prognosis if diagnosed at an early stage. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByCHUANG C, SHEN Y, WU J, TSAI L and LIAO S (2018) IMMUNOBIOLOGIC, CYTOGENETIC AND DRUG RESPONSE FEATURES OF A NEWLY ESTABLISHED CELL LINE (SCRC-1) FROM RENAL SMALL CELL CARCINOMAJournal of Urology, VOL. 163, NO. 3, (1016-1021), Online publication date: 1-Mar-2000.MACKEY J, AU H, HUGH J and VENNER P (2018) GENITOURINARY SMALL CELL CARCINOMA: DETERMINATION OF CLINICAL AND THERAPEUTIC FACTORS ASSOCIATED WITH SURVIVALJournal of Urology, VOL. 159, NO. 5, (1624-1629), Online publication date: 1-May-1998.Vadmal M, Steckel J, Teichberg S and Hajdu S (2018) Primary Neuroendocrine Carcinoma of the Penile UrethraJournal of Urology, VOL. 157, NO. 3, (956-957), Online publication date: 1-Mar-1997.Holmang S, Borghede G and Johansson S (2018) Primary Small Cell Carcinoma of the Bladder: A Report of 25 CasesJournal of Urology, VOL. 153, NO. 6, (1820-1822), Online publication date: 1-Jun-1995.di Sant'agnese P and Cockett A (2018) The Prostatic Endocrine-Paracrine (Neuroendocrine) Regulatory System and Neuroendocrine Differentiation in Prostatic Carcinoma: A Review and Future Directions in Basic ResearchJournal of Urology, VOL. 152, NO. 5 Part 2, (1927-1931), Online publication date: 1-Nov-1994. Volume 146Issue 2 Part 1August 1991Page: 382-388 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordsprostatebladdercarcinomaurogenital systemoat cellkidneyMetricsAuthor Information Mark E. Christopher More articles by this author Allen D. Seftel More articles by this author Kelly Sorenson More articles by this author Martin I. Resnick More articles by this author Expand All Advertisement Loading ...