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Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone

1975; American Psychiatric Association; Volume: 132; Issue: 4 Linguagem: Inglês

10.1176/ajp.132.4.447

1535-7228

George Woody, Charles P. O’Brien, Karl Rickels,

Treatment of Major Depression

Narcotic addicts may manifest symptoms of depression that aggravate their addiction. In this double-blind study of 35 mildly depressed patients in a methadone maintenance program, subjects who received doxepin improved significantly more than control subjects. Even in this short-term study, the reduction in depression was associated with a trend toward better performance in other areas of rehabilitation.