Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck
1996; Springer Science+Business Media; Linguagem: Inglês
10.1007/978-3-642-79798-9_4
ISSN2196-9965
Autores Tópico(s)Galectins and Cancer Biology
ResumoStimulation of T Lymphocytes by antigen or anti-T cell receptor (TCR) antibodies provokes a rapid series of intracellular biochemical changes, leading to the expression of either the helper-inducer or the cytotoxic T cell phenotype (for reviews, see Samelson and Klausner 1992; Veillette and Davidson 1992; Perlmutter et al. 1993 and Weiss and Littman 1994). This response, termed T cell activation, is accompanied by a sudden increase in intracellular phosphotyrosine levels. Importantly, the use of tyrosine protein kinase inhibitors has revealed that tyrosine protein phosphorylation is required for all subsequent events of T cell activation, including stimulation of phosphatidyl inositol (PI) turnover, rise in intracellular calcium, lymphokine secretion and mitogenesis (Mustelin et al. 1990; June et al. 1990).
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