Ritter-type Reactions
1991; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-08-052349-1.00159-1
Autores Tópico(s)Veterinary medicine and infectious diseases
ResumoThe process now known as the Ritter reaction was first described in detail in two papers1,2 published in 1948. Strongly acidic conditions were used to generate a carbenium ion which underwent nucleophilic attack by a nitrile, and further events leading to the isolated product. In its original and most familiar form, hydrolytic work-up produced an amide. However, later investigations showed that in suitable cases intramolecular cyclization could occur, affording a wide range of heterocyclic materials. Although this very general reaction is justly named for Ritter, who recognized and explored its considerable potential, it is not surprising that a few special cases of Ritter-type processes are described in earlier independent reports.3–7 Early work on the Ritter reaction is well served by a number of review articles,8–14 that by Krimen and Cota12 being especially valuable in the present context.
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