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Four-Drug Intracavernous Therapy for Impotence Due to Corporeal Veno-Occlusive Dysfunction

1993; Lippincott Williams & Wilkins; Volume: 149; Issue: 5 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)36371-1

1527-3792

Francesco Montorsi, Giorgio Guazzoni, F. Bergamaschi, Luigi Ferini‐Strambi, Luigi Barbieri, Patrizio Rigatti,

Migraine and Headache Studies

No AccessJournal of Urology1 May 1993Four-Drug Intracavernous Therapy for Impotence Due to Corporeal Veno-Occlusive Dysfunction Francesco Montorsi, Giorgio Guazzoni, Franco Bergamaschi, Luigi Ferini-Strambi, Luigi Barbieri, and Patrizio Rigatti Francesco MontorsiFrancesco Montorsi , Giorgio GuazzoniGiorgio Guazzoni , Franco BergamaschiFranco Bergamaschi , Luigi Ferini-StrambiLuigi Ferini-Strambi , Luigi BarbieriLuigi Barbieri , and Patrizio RigattiPatrizio Rigatti View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36371-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Although veno-occlusive dysfunction is a frequent cause of impotence, a definitive therapeutic strategy has not yet been clearly defined. A total of 56 patients with corporeal veno-occlusive dysfunction diagnosed by dynamic infusion cavernosometry-cavernosography (flow to maintain erection greater than 10ml. per minute and rate of corporeal pressure decrease after interruption of intracavernous infusion greater than 50mm. Hg for 30seconds) not considered suitable candidates for surgery underwent self-injection therapy. A vasoactive mixture composed of 12.1mg./ml. papaverine hydrochloride, 10.1 µgm/mh prostaglandin E1, 1.01mg./ml. phentolamine mesylate and 0.15mg./ml. atropine sulfate was used. After dose titration of the drug mixture 54 patients (95%) were able to obtain sustained rigid erections that guaranteed satisfactory sexual activity. Mean (plus or minus standard error of mean) volume of injected mixture was 0.42 ± 0.09ml. (range 0.25 to 0.90ml.). Four patients (7%) reported transient hypotension that did not recur after the application of a penile rubber band before injection. At a mean followup of 16 months 6 patients (11%) discontinued use of injections, 37 (69%) were satisfied and using the mixture, and 11 (20%) maintained rigid erections using a lower than initial dose. No major complications were encountered. The association of drugs with different mechanisms of action caused a synergism that potentiated the therapeutic activity and reduced side effects by decreasing the total drug dose. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byMcMAHON C, SAMALI R and JOHNSON H (2018) TREATMENT OF INTRACORPOREAL INJECTION NONRESPONSE WITH SILDENAFIL ALONE OR IN COMBINATION WITH TRIPLE AGENT INTRACORPOREAL INJECTION THERAPYJournal of Urology, VOL. 162, NO. 6, (1992-1998), Online publication date: 1-Dec-1999.SOLI M, BERTACCINI A, CARPARELLI F, GOTTI R, CAVRINI V, ANDRISANO V and MARTORANA G (2018) VASOACTIVE COCKTAILS FOR ERECTILE DYSFUNCTION: CHEMICAL STABILITY OF PGE1, PARAVERINE AND PHENTOLAMINEJournal of Urology, VOL. 160, NO. 2, (551-555), Online publication date: 1-Aug-1998.PETERSON C, BENNETT A, HELLSTROM W, KAISER F, MORLEY J, NEMO K, PADMA-NATHAN H, PLACE V, PRENDERGAST J, TAM P, TANAGHO E, TODD L, VARADY J and GESUNDHEIT N (2018) ERECTILE RESPONSE TO TRANSURETHRAL ALPROSTADIL, PRAZOSIN AND ALPROSTADIL-PRAZOSIN COMBINATIONSJournal of Urology, VOL. 159, NO. 5, (1523-1528), Online publication date: 1-May-1998.Bechara A, Casabe A, Cheliz G, Romano S, Rey H and Fredotovich N (2018) Comparative Study of Papaverine Plus Phentolamine Versus Prostaglandin E1 in Erectile DysfunctionJournal of Urology, VOL. 157, NO. 6, (2132-2134), Online publication date: 1-Jun-1997.Sogari P, Teloken C and Vargas Souto C (2018) ATROPINE ROLE IN THE PHARMACOLOGICAL ERECTION TEST: STUDY OF 228 PATIENTSJournal of Urology, VOL. 158, NO. 5, (1760-1763), Online publication date: 1-Nov-1997.Porst H (2018) The Rationale for Prostaglandin E1 in Erectile Failure: A Survey of Worldwide ExperienceJournal of Urology, VOL. 155, NO. 3, (802-815), Online publication date: 1-Mar-1996.Bechara A, Casabe A, Cheliz G, Romano S and Fredotovich N (2018) Prostaglandin E1 Versus Mixture of Prostaglandin E1, Papaverine and Phentolamine in Nonresponders to High Papaverine Plus Phentolamine DosesJournal of Urology, VOL. 155, NO. 3, (913-914), Online publication date: 1-Mar-1996.Montorsi F, Guazzoni G, Barbieri L, Galli L, Rigatti P, Pizzini G and Miani A (2018) The Effect of Intracorporeal Injection Plus Genital and Audiovisual Sexual Stimulation Versus Second Injection on Penile Color Doppler Sonography ParametersJournal of Urology, VOL. 155, NO. 2, (536-540), Online publication date: 1-Feb-1996. Volume 149Issue 5 Part 2May 1993Page: 1291-1295 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.KeywordsatropineimpotencephentolaminepapaverinealprostadilMetricsAuthor Information Francesco Montorsi More articles by this author Giorgio Guazzoni More articles by this author Franco Bergamaschi More articles by this author Luigi Ferini-Strambi More articles by this author Luigi Barbieri More articles by this author Patrizio Rigatti More articles by this author Expand All Advertisement PDF downloadLoading ...