Introduction — Apoptosis in inflammatory cells and diseases
1999; Linguagem: Inglês
10.1007/978-3-0348-8741-0_1
Autores Tópico(s)Neutrophil, Myeloperoxidase and Oxidative Mechanisms
ResumoIt has been recognized for over a century that there are different forms of cell death. One form of cell death, necrosis, is usually the result of severe trauma and is a process that involves loss of membrane integrity and uncontrolled release of cellular contents, often giving rise to inflammatory responses. In contrast, the other form of cell death, apoptosis, is a more physiological process that occurs in a controlled manner and is generally non-inflammatory in nature. For this reason apoptosis is often referred to as programmed cell death. The name itself (apoptosis: Greek for "dropping off", for example leaves from trees) implies a cell death that is part of a normal physiological process [1]. This introduction will review the general characteristics of apoptosis, its regulation and its role in physiology and disease, with the goal to directing the reader to current references and reviews of topics that are outside the scope of this book.
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