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Activation of Surface-Bound Hageman Factor: Pre-Eminent Role of High Molecular Weight Kininogen and Evidence for a New Factor

1976; Springer Nature; Linguagem: Inglês

10.1007/978-1-4684-3267-1_35

2214-8019

Marion E. Webster, Jorge A. Guimarães, Allen P. Kaplan, Robert W. Colman, Jack V. Pierce,

Hemophilia Treatment and Research

Hageman factor (factor XII) is present in plasma as an inactive precursor and is thought to be activated by contact with negatively charged surfaces of particles or macromolecules (1). The activated factor XII then acts directly on its three substrates, factor XI (PTA)(2), prekallikrein (3,4) and plasminogen proactivator (5), thus initiating the plasma proteolytic systems responsible for coagulation, kinin formation and fibrinolysis (Fig. 1).