SUICIDE, NEUROENDOCRINE DYSFUNCTION AND CSF 5-HIAA CONCENTRATIONS IN DEPRESSION
1981; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-08-026382-3.50044-x
AutoresBernard J. Carroll, John F. Greden, Michael Feinberg,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoDisinhibition of the hypothalamic-pituitary-adrenal (HPA) neuroendocrine system is characterized by high CSF cortisol concentrations and abnormal dexamethasone suppression test (DST) results. These two variables are strongly correlated. Abnormal DST results are strongly associated with serious suicidal behavior in melancholic patients. Low CSF 5-HIAA concentrations are dissociated from abnormal DST results. Thus the neuroendocrine disturbance and the neurotransmitter disturbance appear to be unrelated biochemical markers in depressed patients. Since there is evidence that both markers may predict suicide behavior, however, further studies of each marker in the same patients should be performed.
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