Genetic Differences in BALB/c Sublines
1985; Springer Science+Business Media; Linguagem: Inglês
10.1007/978-3-642-70740-7_3
ISSN2196-9965
AutoresJ. Hilgers, R. Van Nie, Dagmar Iványi, John Hilkens, Rob Michalides, J. de Moes, R. Poort-Keesom, V. Kroezen, O. v. Deimling, Ryo Kominami, Roger S. Holmes,
Tópico(s)Virus-based gene therapy research
ResumoThe BALB/c mouse strain, derived from Bagg’s mice via Little, was properly inbred by MacDowell and later Snell, before the emergence of sublines (Staats, 1976). The C3H and other mouse strains developed by Strong, were not inbred enough before subline divergence started, so residual heterozygosity is a major problem and obscures subline differences due to genetic drift (Strong, 1978).
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