GLUCOSE INTOLERANCE DURING DIURETIC THERAPY
1978; Elsevier BV; Volume: 311; Issue: 8066 Linguagem: Inglês
10.1016/s0140-6736(78)90797-3
ISSN1474-547X
AutoresA. Amery, Christopher J. Bulpitt, A. De Schaepdryver, Robert Fagard, J. Hellemans, A Mutsers, P Berthaux, M. Deruyttere, C. T. Dollery, F. Forette, Per Lund‐Johansen, J Tuomilehto,
Tópico(s)Metabolism and Genetic Disorders
Resumo119 elderly, hypertensive patients were followed-up for 1 year and 48 for 2 years in a double-blind, randomised, controlled trial in which they received either placebo or 25-50 mg hydrochlorothiazide and 50-100 mg of triamterene daily. Half of the active treatment group also received 250 mg to 2 g methyldopa daily. After 2 years the active treatment group had an average increase in fasting blood-sugar of 9·6 mg/dl compared with an average fall of 3·1 mg in the placebo group (P<0·001). Blood-glucose rose by an average of 26·6 mg/dl in the active group when determined 1 hour after 50 g oral glucose and decreased by an average of 5·3 mg/dl in patients who had been on placebo for two years (P<0·05). The hyperglycæmic effect of diuretics appeared to be related to potassium loss since, in both groups, impairment of glucose tolerance was most marked in those in whom the serum-potassium decreased over the 2 years.
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