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Faecal microbiota transplantation in recurrent Clostridium difficile infection: Recommendations from the French Group of Faecal microbiota Transplantation

2015; Elsevier BV; Volume: 48; Issue: 3 Linguagem: Inglês

10.1016/j.dld.2015.08.017

1878-3562

Harry Sokol, Tatiana Galpérine, Nathalie Kapel, P Bourlioux, Philippe Seksik, Frédéric Barbut, Julien Scanzi, François Chast, Rui Batista, Francisca Joly, Anne‐Christine Joly, Anne Collignon, Benoît Guéry, Laurent Beaugerie, Laurent Alric, Jean-Paul Aucouturier, Aurelien Amiot, Frédéric Barbut, Rui Batista, Laurent Beaugerie, Pascale Bémer, Robert Benamouzig, Nicolas Benech, Claire Billioud, Gille Boschetti, P Bourlioux, Nour Boubaddi, Guillaume Bouguen, Arnaud Bourreille, Franck Carbonnel, Élodie Cesbron-Métivier, François Chast, Benoît Coffin, Anne Collignon, Michael Collins, Benjamin Davido, T Davion, Aurelilen Dinh, Henri Duboc, Philippe Ducrotté, T. Fraisse, Bertrand Gachot, Tatiana Galpérine, Benoît Guéry, Marielle Guillet, B. Heyman, Anne‐Christine Joly, Francisca Joly, Nathalie Kapel, E Metivier, F. Mille, Alexis Mosca, Biba Nebbad, Gabriel Perlemuter, Thierry Piche, Jean‐Marie Reimund, Matthieu Revest, Jean‐Marc Sabaté, Julien Scanzi, Philippe Seksik, Iradj Sobhani, Harry Sokol, S. Schneider, Caroline Trang, Stéphanie Viennot, M. Viala, Cosmin Sebastian Voican, Frank Zerbib,

Gastrointestinal motility and disorders

Faecal microbiota transplantation is effective for treating recurrent forms of Clostridium difficile infection and its use in this indication is recommended in the most recent European and North American guidelines. In this context, faecal microbiota transplantation is beginning to be performed in France in clinical practice, while the rules governing this procedure have been defined in France only for clinical trials. To unify, secure, and evaluate practice in this field in France, the French Group of Faecal microbiota Transplantation (FGFT) was created in October 2014 with the support of the French National Society of Gastroenterology, the French Infectious Disease Society, and the National Academy of Pharmacy. We present here the deliberations of this group regarding the use of faecal microbiota transplantation for recurrent Clostridium difficile infection. The issues addressed are the indications, therapeutic sequence, delivery procedures, donor selection, methods and conditions of specimen preparation, and traceability.