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Serum Prostate Specific Antigen as Pre-Screening Test for Prostate Cancer

1992; Lippincott Williams & Wilkins; Volume: 147; Issue: 3 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)37402-5

1527-3792

Fernand Labrie, André Dupont, Raul Suburu, Léonello Cusan, Marjolaine Tremblay, José‐Luis Gomez, Jean Emond,

Molecular Biology Techniques and Applications

No AccessJournal of Urology1 Mar 1992Serum Prostate Specific Antigen as Pre-Screening Test for Prostate Cancer Fernand Labrie, André Dupont, Raul Suburu, Leonello Cusan, Marjolaine Tremblay, José-Luis Gomez, and Jean Emond Fernand LabrieFernand Labrie , André DupontAndré Dupont , Raul SuburuRaul Suburu , Leonello CusanLeonello Cusan , Marjolaine TremblayMarjolaine Tremblay , José-Luis GomezJosé-Luis Gomez , and Jean EmondJean Emond View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37402-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Prostate cancer has become the most common cancer and the second cause of death due to cancer in men in North America. Since curative therapies are limited to early stages of the disease, the availability of an efficient, easy to perform, widely acceptable and cost-effective method of early detection of prostate cancer is particularly important. Thus, digital rectal examination, transrectal ultrasonography of the prostate as well as measurements of serum prostate specific antigen (PSA) were performed independently in a series of 1,002 men between 45 and 80 years old randomly selected from the electoral rolls of Quebec City and its vicinity as part of a screening program for prostate cancer. Using this population of randomly chosen men, various cutoff serum PSA values were selected in an attempt to find the optimal decision threshold that would indicate a much greater risk of having prostatic cancer. At a threshold value of 3.0μg./l. the sensitivity and specificity of the test are 80.7 and 89.6%, respectively, while the area under the receiver operating characteristic curve reflecting the accuracy of the test is 87.8 ± 3.3% (plus or minus standard deviation). Moreover, the negative predictive value was estimated at 98.6%, thus leaving only a 1.4% chance of missing cancer when the serum PSA value was 3.0μg./l. or less. Most importantly, such a threshold level of serum PSA retains only 19% of the whole cohort as candidates for transrectal ultrasonography and expensive diagnostic procedures, thus leading to the finding of 1 prostate cancer of 4 such examinations. The present data indicate that simple measurement of serum PSA can be used efficiently as a pre-screening test for prostate cancer in the general population to identify, at a low cost, the subpopulation of men at a much greater risk of having prostate cancer, and who should then be submitted to the more elaborate and expensive diagnostic procedures. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMcGinley S, Luong B, Danforth T and Pranikoff K (2019) Internal Validation and Correlation of 2 Different Prostate Specific Antigen Assays for Prostate Cancer Screening in Community Based MenUrology Practice, VOL. 7, NO. 2, (152-157), Online publication date: 1-Mar-2020.Chen C, Heldt J, Anderson K, Ruckle H, Agarwal G, Smith D, Schlaifer A, Richards G, Arnold D and Baldwin D (2018) Prostate Specific Antigen Levels and Prostate Cancer Detection Rates in Patients With End Stage Renal DiseaseJournal of Urology, VOL. 187, NO. 6, (2061-2067), Online publication date: 1-Jun-2012.Candas B, Labrie F, Gomez J, Cusan L, Chevrette É, Lévesque J and Brousseau G (2018) Relationship Among Initial Serum Prostate Specific Antigen, Prostate Specific Antigen Progression and Prostate Cancer Detection at Repeat Screening VisitsJournal of Urology, VOL. 175, NO. 2, (510-517), Online publication date: 1-Feb-2006.KARAZANASHVILI G and ABRAHAMSSON P (2018) Prostate Specific Antigen and Human Glandular Kallikrein 2 in Early Detection of Prostate CancerJournal of Urology, VOL. 169, NO. 2, (445-457), Online publication date: 1-Feb-2003.Bozeman C, Carver B, Eastham J and Venable D (2018) Treatment Of Chronic Prostatitis Lowers Serum Prostate Specific AntigenJournal of Urology, VOL. 167, NO. 4, (1723-1726), Online publication date: 1-Apr-2002.GERSTENBLUTH R, SEFTEL A, HAMPEL N, OEFELEIN M and RESNICK M (2018) The Accuracy of the Increased Prostate Specific Antigen Level (Greater than or Equal to 20 Ng./Ml.) in Predicting Prostate Cancer: Is Biopsy Always Required?Journal of Urology, VOL. 168, NO. 5, (1990-1993), Online publication date: 1-Nov-2002.Valeri A, Cormier L, Moineau M, Cancel-Tassin G, Azzouzi R, Doucet L, Baschet F, Cussenot I, L'her J, Berthon P, Mangin P, Cussenot O, Morin J and Fournier G (2018) Targeted Screening For Prostate Cancer In High Risk Families: Early Onset Is A Significant Risk Factor For Disease In First Degree RelativesJournal of Urology, VOL. 168, NO. 2, (483-487), Online publication date: 1-Aug-2002.MÄKINEN T, TAMMELA T, HAKAMA M, STENMAN U, RANNIKKO S, ARO J, JUUSELA H, MÄÄTTÄNEN L and AUVINEN A (2018) PROSTATE CANCER SCREENING WITHIN A PROSTATE SPECIFIC ANTIGEN RANGE OF 3 TO 3.9 NG./ML.: A COMPARISON OF DIGITAL RECTAL EXAMINATION AND FREE PROSTATE SPECIFIC ANTIGEN AS SUPPLEMENTAL SCREENING TESTSJournal of Urology, VOL. 166, NO. 4, (1339-1342), Online publication date: 1-Oct-2001.ISOLA J, AUVINEN A, POUTIAINEN M, KAKKOLA L, JÄRVINEN T, MÄÄTTÄNEN L, STENMAN U, TAMMELA T, HAKAMA M and VISAKORPI T (2018) PREDICTORS OF BIOLOGICAL AGGRESSIVENESS OF PROSTATE SPECIFIC ANTIGEN SCREENING DETECTED PROSTATE CANCERJournal of Urology, VOL. 165, NO. 5, (1569-1574), Online publication date: 1-May-2001.Woodrum D, Brawer M, Partin A, Catalona W and Southwick P (2018) INTERPRETATION OF FREE PROSTATE SPECIFIC ANTIGEN CLINICAL RESEARCH STUDIES FOR THE DETECTION OF PROSTATE CANCERJournal of Urology, VOL. 159, NO. 1, (5-12), Online publication date: 1-Jan-1998.Vicini F, Horwitz E, Gonzalez J and Martinez A (2018) Treatment Options for Localized Prostate Cancer Based on Pretreatment Serum Prostate Specific Antigen LevelsJournal of Urology, VOL. 158, NO. 2, (319-325), Online publication date: 1-Aug-1997.Williams P, Eastham J, Culkin D, Mata J, Venable D and Sartor O (2018) INFLUENCE OF HEPATIC FUNCTION ON SERUM LEVELS OF PROSTATE SPECIFIC ANTIGENJournal of Urology, VOL. 158, NO. 5, (1867-1869), Online publication date: 1-Nov-1997.Bangma C, Rietbergen J, Kranse R, Blijenberg B, Petterson K and Schroder F (2018) The Free-To-Total Prostate Specific Antigen Ratio Improves the Specificity of Prostate Specific Antigen in Screening for Prostate Cancer in the General PopulationJournal of Urology, VOL. 157, NO. 6, (2191-2196), Online publication date: 1-Jun-1997.Higashihara E, Nutahara K, Kojima M, Okegawa T, Miura I, Miyata A, Kato M, Sugisaki H and Tomaru T (2018) Significance of Serum Free Prostate Specific Antigen in the Screening of Prostate CancerJournal of Urology, VOL. 156, NO. 6, (1964-1968), Online publication date: 1-Dec-1996.Elgamal A, Cornillie F, Van Poppel H, Van de Voorde W, McCabe R and Baert L (2018) Free-to-Total Prostate Specific Antigen Ratio as a Single Test for Detection of Significant Stage T1c Prostate CancerJournal of Urology, VOL. 156, NO. 3, (1042-1049), Online publication date: 1-Sep-1996.Catalona W, Hudson M, Scardino P, Richie J, Ahmann F, Flanigan R, deKernion J, Ratliff T, Kavoussi L, Dalkin B, Waters W, MacFarlane M and Southwick P (2018) Selection of Optimal Prostate Specific Antigen Cutoffs for Early Detection of Prostate Cancer: Receiver Operating Characteristic CurvesJournal of Urology, VOL. 152, NO. 6 Part 1, (2037-2042), Online publication date: 1-Dec-1994.Feightner J (2018) The Early Detection and Treatment of Prostate Cancer: The Perspective of the Canadian Task Force on The Periodic Health ExaminationJournal of Urology, VOL. 152, NO. 5 Part 2, (1682-1684), Online publication date: 1-Nov-1994. (2018) DiscussionJournal of Urology, VOL. 152, NO. 5 Part 2, (1870-1872), Online publication date: 1-Nov-1994.Littrup P, Goodman A, Mettlin C and Murphy G (2018) Cost Analyses of Prostate Cancer Screening: Frameworks For DiscussionJournal of Urology, VOL. 152, NO. 5 Part 2, (1873-1877), Online publication date: 1-Nov-1994.Partin A and Oesterling J (2018) The Clinical Usefulness of Prostate Specific Antigen: Update 1994Journal of Urology, VOL. 152, NO. 5 Part 1, (1358-1368), Online publication date: 1-Nov-1994.Shinohara K, Wolf J, Narayan P and Carroll P (2018) Comparison of Prostate Specific Antigen with Prostate Specific Antigen Density for 3 Clinical ApplicationsJournal of Urology, VOL. 152, NO. 1, (120-123), Online publication date: 1-Jul-1994.Rommel F, Agusta V, Breslin J, Huffnagle H, Pohl C, Sieber P and Stahl C (2018) The Use of Prostate Specific Antigen and Prostate Specific Antigen Density in the Diagnosis of Prostate Cancer in a Community Based Urology PracticeJournal of Urology, VOL. 151, NO. 1, (88-93), Online publication date: 1-Jan-1994.Keetch D, Catalona W and Smith D (2018) Serial Prostatic Biopsies in Men with Persistently Elevated Serum Prostate Specific Antigen ValuesJournal of Urology, VOL. 151, NO. 6, (1571-1574), Online publication date: 1-Jun-1994.Brawer M, Beatie J, Wener M, Vessella R, Preston S and Lange P (2018) Screening for Prostatic Carcinoma with Prostate Specific Antigen: Results of the Second YearJournal of Urology, VOL. 150, NO. 1, (106-109), Online publication date: 1-Jul-1993.Dupont A, Gomez J, Cusan L, Koutsilieris M and Labrie F (2018) Response to Flutamide Withdrawal in Advanced Prostate Cancer in Progression Under Combination TherapyJournal of Urology, VOL. 150, NO. 3, (908-913), Online publication date: 1-Sep-1993.Colberg J, Smith D and Catalona W (2018) Prevalence and Pathological Extent of Prostate Cancer in Men with Prostate Specific Antigen Levels of 2.9 to 4.0 NG./ML.Journal of Urology, VOL. 149, NO. 3, (507-509), Online publication date: 1-Mar-1993. Volume 147Issue 3 Part 2March 1992Page: 846-851 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordsantigens, differentiationprostatic neoplasmsultrasonic diagnosisMetricsAuthor Information Fernand Labrie More articles by this author André Dupont More articles by this author Raul Suburu More articles by this author Leonello Cusan More articles by this author Marjolaine Tremblay More articles by this author José-Luis Gomez More articles by this author Jean Emond More articles by this author Expand All Advertisement PDF DownloadLoading ...