Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Polymorphism of DC-SIGN ( CD209 ) Promoter in Association with Clinical Symptoms of Dengue Fever

2014; Mary Ann Liebert, Inc.; Volume: 27; Issue: 5 Linguagem: Inglês

10.1089/vim.2013.0119

1557-8976

Layanna Freitas de Oliveira, Clayton Pereira Silva de Lima, Raimunda do Socorro Silva Azevedo, Dafne Silva Furtado de Mendonça, Sueli Guerreiro Rodrigues, Valéria Lima Carvalho, Eliana Vieira Pinto, Andreza Lopes Maia, María Helena Thomaz Maia, Janaína Mota de Vasconcelos, Andréa Luciana Soares da Silva, Márcio Roberto Teixeira Nunes, Leonardo Sena, Pedro Fernando da Costa Vasconcelos, Eduardo José Melo dos Santos,

Viral Infections and Outbreaks Research

C-type lectin DC-SIGN receptor, encoded by CD209, plays a key role in the infection of dendritic cells by dengue virus (DENV). Because the -336A/G SNP (rs4804803) polymorphism in the promoter of CD209 modulates DC-SIGN expression, we investigated the putative association of this polymorphism with DENV infection and its pathogenesis. A control sample of 72 individuals, rigorously selected through a clinical investigation for absence of past dengue fever (DF) was compared to a sample of 168 patients (156 classical DF; 12 dengue hemorrhagic fever), all residents from Pará, Brazil. However, the prevalence of symptoms showed a trend higher in the AA genotype (Wilcoxon test; Z=2.02; p=0.04). Hence, our findings indicate that the G allele downregulates the spectrum of symptoms during the early acute phase of DENV infection, putatively decreasing the viremia, as suggested in the literature.