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Laser Desorption Mass Spectrometry. A Review

1986; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-82724-2_125

2364-9003

Franz Hillenkamp,

Analytical Chemistry and Chromatography

Lasers can be used in a variety of different ways to generate atomic or molecular ions, suitable for mass spectrometric analysis. Most obvious is the photoionization of neutrals in the gas phase. Because the ionization energy of almost all species is larger than the photon energy of the commonly used lasers, photoionization is almost exclusively done by resonant or nonresonant two-photon excitation; the resulting removal of an electron necessarily leads to radical ions. For a few selected references of this technique see e.g.[1–6]. Gas phase irradiation of ions with lasers can also be used for photodissociation in structural analysis[7, 8]. For elemental analysis of solid samples spark plasma ionization mass spectrometry is a well-established technique. Replacement of the spark- by a laser plasma has obvious advantages e.g. for nonconducting samples,and in cases, in which spacial resolution is of interest. Generation of su table laser plasmas requires short pulses and irradiances on the sample of 109 W/cm2 and above. For recent development in this field see e.g.[9–11].