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Localization of hematopoietic progenitor cells in tissue with the anti-My-10 monoclonal antibody.

1985; National Institutes of Health; Volume: 119; Issue: 1 Linguagem: Inglês

W. E. Beschorner, CI Civin, Lewis C. Strauss,

Lymphoma Diagnosis and Treatment

Putative hematopoietic progenitor cells were localized in human lymphoid and nonlymphoid tissues with the use of the anti-My-10 antibody and avidin-biotin immunoperoxidase. Groups of My-10+ round mononuclear cells were evident in the splenic marginal zone near the follicular mantle. My-10+ cells were also evident in the hepatic portal triads and rare cells were seen near Peyer's patches. Except for My-10+ endothelial cells, there was no staining of the thymus, lymph node, skin, or kidney specimens.