Portal de Periódicos da CAPES

Influence of Age and Endocrine Factors on the Volume of Benign Prostatic Hyperplasia

1991; Lippincott Williams & Wilkins; Volume: 145; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(17)38353-2

1527-3792

Alan W. Partin, Joseph E. Oesterling, Jonathan I. Epstein, Richard Horton, Patrick C. Walsh,

Urinary Bladder and Prostate Research

No AccessJournal of Urology1 Feb 1991Influence of Age and Endocrine Factors on the Volume of Benign Prostatic Hyperplasia Alan W. Partin, Joseph E. Oesterling, Jonathan I. Epstein, Richard Horton, and Patrick C. Walsh Alan W. PartinAlan W. Partin More articles by this author , Joseph E. OesterlingJoseph E. Oesterling More articles by this author , Jonathan I. EpsteinJonathan I. Epstein More articles by this author , Richard HortonRichard Horton More articles by this author , and Patrick C. WalshPatrick C. Walsh More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38353-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail To determine whether endocrine factors influence the volume of benign prostatic hyperplasia (BPH), 23 hormonal factors were measured in the serum of 64 men ages 42 to 71 years with low volume prostatic cancer and these levels were correlated with the volume of benign hyperplastic tissue in their radical prostatectomy specimens. With age there was a significant increase in the volume of BPH. Also with age there was a significant decrease in the serum levels of free testosterone, androstenedione, dehydroepiandronsterone (DHA), dehydroepiandronsterone sulphate (DHA-S), Δ5-androstenediol, and 17-hydroxypregnenolone, and a significant increase in sex hormone-binding globulin (SHBG), LH, and FSH. When BPH volume and hormone levels were corrected for age, BPH volume correlated positively with free testosterone, estradiol, and estriol. These data indicate that with age patients with larger volumes of BPH have higher serum androgen and estrogen levels suggesting that serum androgen and estrogen levels may be factors in the persistent stimulation of BPH with age. If so, therapeutic attempts at lowering plasma testosterone levels, reducing estrogen levels, or blocking androgenic stimulation through other mechanisms may interfere with the progression of BPH with age. Conversely, the fact that androgen production declines gradually with age may explain the observation that only 20 to 30% of men who live to age 80 require surgical treatment for urinary obstruction from BPH. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByUhlman M, Sun L, Stackhouse D, Polascik T, Mouraviev V, Robertson C, Albala D and Moul J (2018) Tumor Percent Involvement Predicts Prostate Specific Antigen Recurrence After Radical Prostatectomy Only in Men With Smaller ProstateJournal of Urology, VOL. 183, NO. 3, (997-1002), Online publication date: 1-Mar-2010.Chang I, Oh S and Kim S (2018) A Possible Relationship Between Testosterone and Lower Urinary Tract Symptoms in MenJournal of Urology, VOL. 182, NO. 1, (215-220), Online publication date: 1-Jul-2009.Freedland S, Platz E, Presti J, Aronson W, Amling C, Kane C and Terris M (2018) Obesity, Serum Prostate Specific Antigen and Prostate Size: Implications for Prostate Cancer DetectionJournal of Urology, VOL. 175, NO. 2, (500-504), Online publication date: 1-Feb-2006.GRAYHACK J, KOZLOWSKI J and LEE C (2018) THE PATHOGENESIS OF BENIGN PROSTATIC HYPERPLASIA: A PROPOSED HYPOTHESIS AND CRITICAL EVALUATIONJournal of Urology, VOL. 160, NO. 6 Part 2, (2375-2380), Online publication date: 1-Dec-1998.Cardillo M, Berchem G, Tarkington M, Krajewski S, Krajewski M, Reed J, Tehan T, Ortega L, Lage J and Gelmann E (2018) Resistance to Apoptosis and Up Regulation of Bcl-2 In Benign Prostatic Hyperplasia After Androgen DeprivationJournal of Urology, VOL. 158, NO. 1, (212-216), Online publication date: 1-Jul-1997.Daniell H (2018) Larger Prostatic Adenomas in Obese Men with No Associated Increase in Obstructive UropathyJournal of Urology, VOL. 149, NO. 2, (315-317), Online publication date: 1-Feb-1993. Volume 145Issue 2February 1991Page: 405-409 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.KeywordsestrogenBPHtestosteroneandrogenMetricsAuthor Information Alan W. Partin More articles by this author Joseph E. Oesterling More articles by this author Jonathan I. Epstein More articles by this author Richard Horton More articles by this author Patrick C. Walsh More articles by this author Expand All Advertisement PDF DownloadLoading ...