Chitosan-poly(aminopropyl/phenylsilsesquioxane) hybrid nanocomposite membranes for antibacterial and drug delivery applications
2014; Wiley; Volume: 64; Issue: 2 Linguagem: Inglês
10.1002/pi.4789
ISSN1097-0126
AutoresSubba Venkata Krishna Rao Kummari, Kummara Madhusudana Rao, Ramasubba Reddy Palem, Sivagangi Reddy Nagellea, Yury Shchipunov, Chang‐Sik Ha,
Tópico(s)Antimicrobial agents and applications
ResumoPolymer InternationalVolume 64, Issue 2 p. 293-302 Research Article Chitosan–poly(aminopropyl/phenylsilsesquioxane) hybrid nanocomposite membranes for antibacterial and drug delivery applications Subba Venkata Krishna Rao Kummari, Corresponding Author Subba Venkata Krishna Rao Kummari Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, IndiaCorrespondence to: K.S.V. Krishna Rao, Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, India. E-mail: [email protected]; Chang-Sik Ha, Department of Polymer Science and Engineering, Pusan National University, Busan 609-735, Korea. E-mail: [email protected]Search for more papers by this authorMadhusudana Rao Kummara, Madhusudana Rao Kummara Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735 KoreaSearch for more papers by this authorRamasubba Reddy Palem, Ramasubba Reddy Palem Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, IndiaSearch for more papers by this authorSivagangi Reddy Nagellea, Sivagangi Reddy Nagellea Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, IndiaSearch for more papers by this authorYury Shchipunov, Yury Shchipunov Institute of Chemistry, Far East Department, Russian Academy of Sciences, Vladivostok, 690022 RussiaSearch for more papers by this authorChang-Sik Ha, Corresponding Author Chang-Sik Ha Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735 KoreaCorrespondence to: K.S.V. Krishna Rao, Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, India. E-mail: [email protected]; Chang-Sik Ha, Department of Polymer Science and Engineering, Pusan National University, Busan 609-735, Korea. E-mail: [email protected]Search for more papers by this author Subba Venkata Krishna Rao Kummari, Corresponding Author Subba Venkata Krishna Rao Kummari Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, IndiaCorrespondence to: K.S.V. Krishna Rao, Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, India. E-mail: [email protected]; Chang-Sik Ha, Department of Polymer Science and Engineering, Pusan National University, Busan 609-735, Korea. E-mail: [email protected]Search for more papers by this authorMadhusudana Rao Kummara, Madhusudana Rao Kummara Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735 KoreaSearch for more papers by this authorRamasubba Reddy Palem, Ramasubba Reddy Palem Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, IndiaSearch for more papers by this authorSivagangi Reddy Nagellea, Sivagangi Reddy Nagellea Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, IndiaSearch for more papers by this authorYury Shchipunov, Yury Shchipunov Institute of Chemistry, Far East Department, Russian Academy of Sciences, Vladivostok, 690022 RussiaSearch for more papers by this authorChang-Sik Ha, Corresponding Author Chang-Sik Ha Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735 KoreaCorrespondence to: K.S.V. Krishna Rao, Department of Chemistry, Yogi Vemana University, Kadapa – 516 003, India. E-mail: [email protected]; Chang-Sik Ha, Department of Polymer Science and Engineering, Pusan National University, Busan 609-735, Korea. E-mail: [email protected]Search for more papers by this author First published: 15 July 2014 https://doi.org/10.1002/pi.4789Citations: 16Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract We fabricated hybrid (CSSQ) membranes from chitosan and poly(aminopropyl/phenylsilsesquioxane) (PAPSQ) blends via a sol–gel reaction and solution casting followed by crosslinking with glutaraldehyde. The CSSQ membranes were then used for loading of 5-fluorouracil (5-FU) as an anticancer drug as well as templates for the production of silver nanoparticles (AgNPs). The physicochemical properties of the CSSQ membranes were examined using UV-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis and scanning electron microscopy (SEM). SEM results showed the controllable formation of AgNPs around PAPSQ. CSSQ–Ag nanocomposite membranes exhibited good antibacterial activity towards both Escherichia coli and Bacillus subtilis, while the CSSQ membranes worked as good carriers for controlled release of 5-FU as model drug. 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Citing Literature Supporting Information Filename Description pi4789-sup-0001-SchemeS1.docWord document, 53.5 KB Synthesis route for synthesis of PAPSQ. pi4789-sup-0002-FigureS1.docWord document, 88.5 KB 29SiCP-MAS NMR spectra of PAPSQ pi4789-sup-0003-FigureS2.docWord document, 2.2 MB Antibacterial activity of CSSQ-Ag hybrid membranes for (A) CSSQ-0 (a) CSSQ-1 (b) CSSQ-2 (c) CSSQ-3 (d) as controls and CSSQ-Ag-0 (a1) CSSQ-Ag-1 (b1) CSSQ-Ag-2 (c1) CSSQ-Ag-3 (d1) as samples on (A) E.coli and (B) Bacilli subtilis. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume64, Issue2February 2015Pages 293-302 ReferencesRelatedInformation
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