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Histologic characteristics of cells cultured from rat placental tissue

1976; Elsevier BV; Volume: 124; Issue: 4 Linguagem: Inglês

10.1016/0002-9378(76)90103-4

1097-6868

Frederick G. Ferguson, Joy Palm,

Birth, Development, and Health

Laboratory animals, especially rats, have provided a comparative model for extensive research on maternal-fetal relationships. To identify individual placental cells for subsequent immunologic analysis, cultures of rat placentas were studied. Five cell types were observed, including: two histologically distinct giant cells, mononucleate and multinucleate, apparently formed by amitosis and fusion, respectively; small round cells; polygonal cells, probably cytotrophoblasts. Of particular interest are the small round cells which are phagocytic and morphologically similar to macrophages, cells known to be important in the immune response.