Hypothyroidism and carpal tunnel syndrome: A meta‐analysis
2014; Wiley; Volume: 50; Issue: 6 Linguagem: Inglês
10.1002/mus.24453
ISSN1097-4598
Autores Tópico(s)Myasthenia Gravis and Thymoma
ResumoABSTRACT This study aimed to assess the magnitude of the association between hypothyroidism and carpal tunnel syndrome (CTS). Eighteen studies were included in a random‐effects meta‐analysis. A meta‐analysis of the studies that did not control their estimates for any confounder showed an association between a thyroid disease (hypo‐ or hyperthyroidism) and CTS ( N = 9,573, effect size [ES] = 1.32 (95% confidence interval [CI], 1.04–1.68) and between hypothyroidism and CTS ( N = 64,531, ES = 2.15 [95% CI, 1.64–2.83]). When a meta‐analysis limited to the studies that controlled their estimates for some potential confounders, the association between a thyroid disease and CTS disappeared ( N = 4,799, ES = 1.17 [95% CI, 0.71–1.92], I 2 = 0%), and the effect size for hypothyroidism largely attenuated ( N = 71,133, ES = 1.44 [95% CI, 1.27–1.63], I 2 = 0%). Moreover, there was evidence of publication bias. This meta‐analysis found only a modest association between hypothyroidism and CTS. Confounding and publication bias may still account for part of the remaining excess risk. Muscle Nerve 50: 879–883, 2014
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