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Localization and quantitation of lithium in rat tissue following intraperitoneal injections of lithium chloride

1976; Elsevier BV; Volume: 25; Issue: 1 Linguagem: Inglês

10.1016/0014-4800(76)90015-0

1096-0945

Susan C. Nelson, Mary M. Herman, Klaus G. Bensch, R. Sher, Jack D. Barchas,

Pharmacological Effects and Toxicity Studies

The quantitative distribution of lithium was determined in the thyroid, thymus, heart, adrenal, kidney, and testis of rats intraperitoneally injected with 1 meq Li/kgm every 12 hr for 14 days. The lithium was analyzed in intact tissue sections by radiographic dielectric track registration techniques. A relatively uniform distribution was found in the thyroid and heart, with nonuniform localization in the thymus, adrenal, kidney, and testis. The highest lithium concentrations were found in the papillary area of the kidney, followed by the thyroid, which contained about half the amount observed in renal papillae but two to five times the levels in other tissues examined. In the thymus, the lithium concentration in the cortex was greater than in the medulla, whereas in the adrenal it was greater in the medulla than in the cortex. This pattern of lithium distribution cannot be accounted for by differences in vascularization since the medulla of both organs is more vascularized than their cortex.