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Interleukin‐17+CD8+ T Cells Are Enriched in the Joints of Patients With Psoriatic Arthritis and Correlate With Disease Activity and Joint Damage Progression

2014; Wiley; Volume: 66; Issue: 5 Linguagem: Inglês

10.1002/art.38376

2326-5205

Bina Menon, Nicola Gullick, Gina Walter, Megha Rajasekhar, Toby Garrood, Hayley G. Evans, Leonie S. Taams, Bruce Kirkham,

Autoimmune and Inflammatory Disorders Research

Psoriatic arthritis (PsA) is associated with HLA class I genes, in contrast to the association with HLA class II in rheumatoid arthritis (RA). Since IL-17+ cells are considered important mediators of synovial inflammation, we sought to determine whether IL-17-producing CD8+ T cells may be found in the joints of patients with PsA and whether these cells might contribute to the disease process.