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Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin.

1988; National Institutes of Health; Volume: 133; Issue: 1 Linguagem: Inglês

Fabio Facchetti, C. De Wolf‐Peeters, D Y Mason, Karen Pulford, Joost J. van den Oord, V. Desmet,

Lymphadenopathy Diagnosis and Analysis

To elucidate the lineage of plasmacytoid T cells, their immunophenotype was studied in reactive lymph nodes with a broad panel of monoclonal antibodies. Plasmacytoid T cells expressed several myelomonocytic markers, and almost all markers highly selective for macrophages. They lacked granulocyte-associated and B or T lymphocyte-associated antigens. These results provide strong evidence that plasmacytoid T cells are of monocyte lineage.