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Importance of the nucleolus in the initiation of DNA synthesis in mammalian cells

1973; Elsevier BV; Volume: 78; Issue: 1 Linguagem: Inglês

10.1016/0014-4827(73)90057-8

1090-2422

J.M.R. Hatfield, P P Dendy, F. L. Meyskens, A. B. Rickinson,

Reproductive Biology and Fertility

Abstract Two independent techniques have been used to study the effects of nucleolar damage on the entry of cells into the DNA synthetic phase. Experiments have been performed with HEp/2 cells, mouse L cells, freshly cultured embryonic mouse fibroblast cells and freshly cultured monkey kidney cells. All the results confirm previous reports that when cells have proceeded more than 1–2 h into the G1 phase the onset of the next DNA synthetic phase is not delayed by nucleolar damage. However, nucleolar damage at about the time of cell division appears to delay entry into S phase for certain cell types.