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Milk oral immunotherapy is effective in school‐aged children

2012; Wiley; Volume: 102; Issue: 2 Linguagem: Inglês

10.1111/j.1651-2227.2012.02815.x

1651-2227

Susanna Salmivesi, Matti Korppi, Mika J. Mäkelä, Marita Paassilta,

Asthma and respiratory diseases

Abstract Aims: To study the efficacy of oral immunotherapy (OIT) in schoolchildren with cow’s milk (CM) allergy (CMA). Methods: Twenty‐eight children aged 6–14 years with CMA documented by oral challenge were enrolled into a randomized, double‐blind, placebo‐controlled OIT study. In the active treatment, CM protein amount was increased during 23 weeks from 0.06 mg to a maximum of 6400 mg (200 mL of milk). Results: Twenty‐four (86%) patients completed the protocol: 16/18 in active and 8/10 in placebo groups. All children in the active and 2/3 in the placebo group suffered from symptoms considered by the parents as induced by milk. The children were contacted by phone 12 months later, and 13 (81%) used daily CM or milk products corresponding 6400 mg of CM protein. After double‐blind OIT, all 10 children in the placebo group completed successfully an open‐label OIT by an identical protocol, and all used daily CM or milk products 6 months later. Three to 3.5 years later, one child more had discontinued daily milk use. Thus, the long‐term success rate was 22/28 (79%). Conclusions: This placebo‐controlled, double‐blind study confirmed that OIT was effective in desensitizing schoolchildren with CMA. With occasional exceptions, the reached desensitization sustained for more than 3 years.