The relevance of a hypoxic tumour microenvironment in prostate cancer
2009; Wiley; Volume: 105; Issue: 1 Linguagem: Inglês
10.1111/j.1464-410x.2009.08921.x
ISSN1464-410X
AutoresGrant D. Stewart, James A. Ross, Duncan B. McLaren, Christopher Parker, Fouad K. Habib, Antony C.P. Riddick,
Tópico(s)Hepatocellular Carcinoma Treatment and Prognosis
ResumoResearch into the hypoxic tumour microenvironment is accelerating and the reversal of hypoxia is increasingly being suggested as a mechanism for improving cancer treatment. Recent studies have suggested that hypoxia is also a feature in prostate cancer and is associated with a poor prognosis. Hypoxia has been shown to cause radio-resistance and hence hamper one of the major treatments for prostate cancer. However, unlike other solid tumours, such as cervical and head-and-neck cancer, there are inconsistencies and unanswered questions about the relevance of hypoxia in prostate cancer. This review outlines the role of low-oxygen conditions in prostate cancer and the areas where further studies are required.
Referência(s)