Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events
2002; Elsevier BV; Volume: 100; Issue: 4 Linguagem: Inglês
10.1182/blood.v100.4.1505.h81602001505_1505_1507
ISSN1528-0020
AutoresSurinder S. Sahota, Francesco Forconi, Christian H. Ottensmeier, Drew Provan, David Oscier, Terry J. Hamblin, Freda K. Stevenson,
Tópico(s)Immunodeficiency and Autoimmune Disorders
ResumoThere exists a wide spectrum of IgM-secreting B-cell tumors with different clinical behavior. Knowledge of the VH gene status can reveal their origin and clonal history. For Waldenstrom macroglobulinemia (WM), a distinct subtype of lymphoplasmacytic lymphoma, early data on limited sequences showed evidence for somatic mutation. A recent report of one case demonstrated intraclonal mutational activity occurring after transformation, a characteristic of germinal center lymphomas. To extend the investigation, we have analyzed 7 cases of WM. VH genes were somatically mutated with no evidence of intraclonal variation in all cases. In contrast to IgM-secreting multiple myeloma, there was no evidence for isotype switch transcripts in any of the cases. These data support the concept that typical WM is derived from a B cell that has undergone somatic mutation prior to transformation, at a point where isotype switch events have not been initiated.
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