Molecular mechanisms of the PRL phosphatases
2012; Wiley; Volume: 280; Issue: 2 Linguagem: Inglês
10.1111/j.1742-4658.2012.08565.x
ISSN1742-4658
AutoresPablo Ríos, Xun Li, Maja Köhn,
Tópico(s)Endoplasmic Reticulum Stress and Disease
ResumoThe phosphatases of regenerating liver (PRLs) are an intriguing family of dual specificity phosphatases due to their oncogenicity. The three members are small, single domain enzymes. We provide an overview of the phosphatases of regenerating liver, compare them to related phosphatases, and review recent reports about each phosphatase. Finally, we discuss similarities and differences between the phosphatases of regenerating liver, focusing on their molecular mechanisms and signalling pathways.
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