Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Characterization of the membrane-associated component.
1987; Elsevier BV; Volume: 262; Issue: 34 Linguagem: Inglês
10.1016/s0021-9258(18)49281-2
ISSN1083-351X
AutoresEdgar Pick, Yael Bromberg, Sally Shpungin, R Gadba,
Tópico(s)Receptor Mechanisms and Signaling
ResumoSodium dodecyl sulfate (SDS) was shown to elicit NADPH-dependent superoxide (0;) production by a cell-free system derived from sonically disrupted resting guinea pig macrophages (Bromberg, Y., and Pick, found in the M, = 28,000-1 1,000 range while the bulk of cytochrome bs59 eluted in the M, = 113,000-7 1,000 range).We propose that A is distinct from cytochrome bbBB and represents a membrane-associated component in an amphiphile-activated electron transport chain from NADPH to oxygen. Phagocytic cells respond to certain membrane stimulants
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